A study of bias should include why we prefer things, such as certain sounds, like a favorite song. Let’s define a “feel good” area of the brain, before we explore how sounds interact there. First, it’s important to understand - Functions in the brain don’t really reside in places, but rather the connections between places. A group of cells can have multiple functions, depending on who they’re talking to. In other words, it is the brain’s pathways that allow us to have cognition. The mesolimbic pathway connects the ventral tegmental area, or VTA, in the midbrain, and the nucleus accumbens in the ventral striatum. The VTA is one of the few groups of cells in the brain that create dopamine, the powerful reward neurotransmitter. When the VTA inputs dopamine to the nucleus accumbens, this mesolimbic pathway elicits a strong sense of reward and enhances motivation. The fact that dopamine is the prominent chemical here, makes this one of the most powerful reward connections in the brain, and anything that enhances this connection will likely produce a strong, sometimes addictive, sense of reward. Let’s study how sounds can interact with these structures and this pathway.